Leptospirosis pathogenesis immunity and diagnosis pdf

Pathogenesis, immunity, and diagnosis leptospirosis is among the most important zoonotic diseases worldwide. Pathogenesis and clinical manifestations of leptospira. However, the mechanisms of pathogenesis of leptospira are largely unknown. The differential diagnosis must include common viral infections, such as. Practitioners should consider leptospirosis as a possible diagnosis. Current diagnosis is antiquated which hampers outpatient. Completion of the genomic sequences of leptospires has facilitated advances in diagnosis and prevention of the disease, and yielded insight into its pathogenesis. Tajiki and salomao, 1996, its precise role in the disease pathophysiology is still under debate. Leptospirosis is a zoonosis caused by pathogenic bacteria from the genus leptospira 1. Leptospirosis is among the most important zoonotic diseases worldwide. Identification of other protective antigens involved in immunity to leptospirosis will. The severity of the leptospirosis depends on a host immunity, b virulence of infecting strain, and c the number of infecting leptospires. The etiology of leptospirosis was demonstrated independently in 1915 in japan and germany 207. Humans are accidental hosts of pathogenic leptospira.